Covid-19, Generic Medicines

Can Ivermectin treat COVID-19? Coronavirus Investigational Treatments

Ivermectin treat COVID-19

What is Ivermectin?

Ivermectin tablets are currently a FDA approved medicine for treatment of intestinal parasitic worms, parasitic diseases, Strongyloides stercoralis and Onchocerca volvulus.

Recently ivermectin has also been studied to treat a range of viruses.

Clinical trials have been conducted on people to test how well ivermectin works against COVID-19. Currently there is a low level of certainty whether ivermectin helps treat COVID-19 and more studies are needed.

Invermectin has been established as safe for use in humans, but only at the recommended dosage level.
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the virus that causes COVID-19 (coronavirus disease 2019)

What is COVID-19?

COVID-19 is the disease caused by an infection of the SARS-CoV-2 virus, first identified in the city of Wuhan, in China’s Hubei province in December 2019. COVID-19 was previously known as 2019 Novel Coronavirus (2019-nCoV) respiratory disease before the World Health Organization (WHO) declared the official name as COVID-19 in February 2020.

The SARS-CoV-2 virus belongs to the family of viruses called coronaviruses, which also includes the viruses that cause the common cold, and the viruses that cause more serious infections such as severe acute respiratory syndrome (SARS), which was caused by SARS-CoV in 2002, and Middle East respiratory syndrome (MERS), which was caused by MERS-CoV in 2012. Like the other coronaviruses, the SARS-CoV-2 virus primarily causes respiratory tract infections, and the severity of the COVID-19 disease can range from mild to fatal.

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IVERHEAL 12MG (IVERMECTIN 12MG)

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Ivermectin is the active ingredient in Iverheal 12mg. The tablet contains 12 mg of salt, which has anti-parasitic properties. The drug is best known for its ability to combat intestinal parasites. If you have a worm infection in the stomach, you can take medication to see how it affects the parasites’ development and the problems they cause in the body. Buy Iverheal 12mg Ivermectin 12 mg now with 10% discount.

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Iverheal 3mg is a medicine used widely against the treatment of infection caused by different parasites. It is recommended to consult with a medical practitioner before starting your medication with Iverheal 3mg. There is some information that also comes in the package of medicine. You can read all the instructions and they give you some ideas about the conception of medicine. Iverheal 3mg can be purchased from a variety of sources, including online and offline stores. Iverheal 3 online because online shopping is the best option to buy medicines. You can buy with legit and trustworthy website called genericpride.com

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Is Ivermectin an approved medicine by the FDA?

Ivermectin tablets (Stromectol) are an FDA approved medicine for treatment of intestinal worms Strongyloides stercoralis and Onchocerca volvulus.

Ivermectin cream 1% (Soolantra) is FDA approved for treatment of rosacea.

Ivermectin is not FDA approved to treat COVID-19.

Ivermectin tablets are also used off-label for a number of other conditions.

Ivermectin intended for animal use should not be taken by humans.

The WHO Therapeutics and COVID-19 living guideline: Ivermectin

The WHO Therapeutics and COVID-19 living guideline is the World Health Organization’s (WHO) most up-to-date recommendations of treatments of COVID-19.

Their recommendation is that ivermectin should not used in patients with COVID-19 unless it is in a research setting, as part of a clinical trial.

This recommendation is the result of a systematic review of randomised clinical trials that used ivermectin for COVID-19. After analysing the information from these studies, they believe that there is a high degree of uncertainty on whether ivermectin is helpful or harmful in treating COVID-19.

The uncertainty in some of the ivermectin trials for COVID-19 is due to

serious risk of bias

serious risk of imprecision.

There are far fewer randomized controlled trials (RCT) for ivermectin compared to other COVID treatments. The RCT for ivermectin included multiple small trials, that had fewer patients enrolled and had fewer events recorded.

More RCT are needed with higher quality of evidence to determine if ivermectin is successful at treating COVID-19.

The NIH COVID-19 Treatment Guidelines: Ivermectin

The NIH COVID-19 Treatment Guidelines is the National Institutes of Health (NIH) most up-to-date recommendations of treatments of COVID-19.

Their recommendation is there is insufficient evidence to recommend either for or against the use of ivermectin for the treatment of COVID-19.

The panel reviewed a number of key studies before making this recommendation. The studies show a range of results after using ivermectin from no benefits or worsening of disease, to shorter time to resolve symptoms of COVID-19 and lower mortality rates. The panel noted most of these studies had:
incomplete information

significant methodological limitations (small sample size, inconsistent dosing and dose schedules, open label studies, other medications taken at the same time, severity of COVID-19 not described, and outcome measures not clearly defined).

They believe there needs to be more adequately powered, well designed and well conducted clinical trials with results that provide more specific and evidence based information on whether ivermectin can treat COVID-19 effectively.

IVERCOR-COVID-19 trial

The IVERCOR-COVID-19 trial was a randomized, double-blind, placebo controlled trial involving 501 patients. The aim of this trial was to determine whether ivermectin treatment could prevent hospitalization of individuals with early COVID-19. One group was treated with ivermectin plus standard treatment and the other group was treated with placebo with standard treatment. Patients were not allowed to take hydroxychloroquine, chloroquine or antiviral drugs.

The results of this trial were published on 2 July 2021 showed that:

The percentage of patients that needed hospitalization was 5.6% in the ivermectin treatment group and 8.4% in the placebo group, but the difference between the two groups was not statistically significant.

There was no statistically significant difference in median time from patient enrollment to hospitalization between the treatment groups. The ivermectin treatment group median time to hospitalization was 3.5 days and placebo group 3 days.

Read Also : Can COVID-19 Lead To Erectile Dysfunction / Impotence?

There was no statistically significant difference in mean time from study enrolment until a patient was put on invasive mechanical ventilatory support (MVS). The ivermectin treatment group was 5.25 days compared to the placebo group which was 10 days.

The limitations in this study was noted as a:

low percentage of hospitalized patients
the mean dose of ivermectin was 192.37  μg/kg/day which was below the dose proposed as probably being effective.

PRINCIPLE TRIAL

The PRINCIPLE trial is a current trial investigating treatments for COVID-19 patients in the community who are more at risk of serious illness. The study is investigating a number of different treatments including ivermectin.

Participants in the ivermectin part of the trial will be:

between the age 18 and 64 years old
with a underlying health condition or shortness of breath due to COVID-19
must join trial within first 14 days of covid-19 symptoms or a positive test
will be assigned to receive 3 day course of oral ivermectin treatment
they will be compared to a group of patients receiving standard NHS COVID-19 care.
The ivermectin part of this trial started in June 2021 and results will be published when available.

How is Ivermectin thought to work on COVID-19?

For the SARS-CoV-2 virus to make you sick, it has to first infect your cells.

Then while inside the cell, the virus makes heaps of copies of itself, so it can spread around your body.

The virus also has ways of reducing the way your body fights the infection.

During the infection of the cell, some viral proteins go into the cell nucleus, and from here they can decrease the body’s ability to fight the virus, which means the infection can get worse.

To get into the nucleus the viral proteins need to bind a cargo transporter which lets them in.

Ivermectin can block the cargo transporter, so the viral proteins can’t get into the nucleus. This is how the scientists believe Ivermectin works against SARS-CoV-2 virus.

By taking Ivermectin, it means the body can fight the infection like normal, because its antiviral response hasn’t been reduced by the viral proteins.

How should I take ivermectin?

Never take ivermectin in larger amounts, or for longer than recommended by your doctor. Follow all directions on your prescription label.

Take ivermectin on an empty stomach, at least 1 hour before or 2 hours after a meal.
Ivermectin is usually given as a single dose. Take this medicine with a full glass of water.

To effectively treat your infection, you may need to take ivermectin again several months to a year after your first dose.

If you have a weak immune system (caused by disease or by using certain medicine), you may need to take more than one dose of ivermectin. Some people who have a weak immune system need to take this medicine on a regular basis. Follow your doctor’s instructions.

To make sure this medicine is working, you may need to provide frequent stool samples.

Store this medicine at room temperature away from moisture and heat.

Ivermectin side effects

Get emergency medical help if you have signs of an allergic reaction to ivermectin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:

eye pain or redness, puffy eyes, problems with your vision;
severe skin rash, itching, or rash with pus;
confusion, change in your mental status, balance problems, trouble walking;
fever, swollen glands, stomach pain, joint pain, swelling in your hands or feet;
fast heart rate, trouble breathing;
loss of bladder or bowel control;
neck or back pain, seizure (convulsions); or
a light-headed feeling, like you might pass out.
Common ivermectin side effects may include:
headache, muscle aches;
dizziness;
nausea, diarrhea; or
mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Ivermectin Dosage

Usual Adult Dose for Onchocerciasis

0.15 mg/kg orally once every 12 months
Patients with heavy ocular infection may require retreatment every 6 months. Retreatment may be considered at intervals as short as 3 months.

Dosage guidelines based on body weight:

15 to 25 kg: 3 mg orally one time
26 to 44 kg: 6 mg orally one time
45 to 64 kg: 9 mg orally one time
65 to 84 kg: 12 mg orally one time
85 kg or more: 0.15 mg/kg orally one time

Usual Adult Dose for Strongyloidiasis

0.2 mg/kg orally once

In immunocompromised (including HIV) patients, the treatment of strongyloidiasis may be refractory requiring repeated treatment (i.e., every 2 weeks) and suppressive therapy (i.e., once a month), although well-controlled studies are not available. Cure may not be achievable in these patients.

Dosage guidelines based on body weight:

15 to 24 kg: 3 mg orally one time
25 to 35 kg: 6 mg orally one time
36 to 50 kg: 9 mg orally one time
51 to 65 kg: 12 mg orally one time
66 to 79 kg: 15 mg orally one time
80 kg or more: 0.2 mg/kg orally one time

Usual Adult Dose for Ascariasis

0.2 mg/kg orally once

Usual Adult Dose for Cutaneous Larva Migrans

0.2 mg/kg orally once

Usual Adult Dose for Filariasis

0.2 mg/kg orally once

Study (n=26,000)

Mass treatment in Papua, New Guinea:

Bancroftian filariasis: 0.4 mg/kg orally once yearly (with a single annual dose of diethylcarbamazine 6 mg/kg), for 4 to 6 years

Usual Adult Dose for Scabies

0.2 mg/kg orally once, and repeated in 2 weeks

Ivermectin therapy may be combined with a topical scabicide.

Usual Pediatric Dose for Filariasis

Study (n=26,000)

Mass treatment in Papua, New Guinea:

Bancroftian filariasis:

5 years or older: 0.4 mg/kg orally once yearly (with a single annual dose of diethylcarbamazine 6 mg/kg), for 4 to 6 years

Renal Dose Adjustments

Currently Data not available

Liver Dose Adjustments

Currently Data not available

Dose Adjustments

Retreatment is required because ivermectin has no activity against adult onchocerca volvulus parasites which tend to reside in subcutaneous nodules. Surgical excision of these nodules may be considered to eliminate the adult reproduction of microfilariae.

Patients with crusted scabies may require two or more doses of ivermectin spaced at one to two week intervals.

Precautions For Ivermectin

Cutaneous, systemic and/or ophthalmological reactions have been reported with other microfilaricidal drugs. Allergic and inflammatory reactions (the Mazzotti reaction) may occur with ivermectin, probably due to the death of the microfilariae. Patients treated with ivermectin therapy for onchocerciasis may experience these reactions in addition to clinical adverse reactions possibly, probably, or definitely related to the therapy itself. The treatment of severe Mazzotti reactions has not been subjected to controlled clinical studies. Oral or intravenous rehydration, corticosteroids, antihistamines, acetaminophen and/or aspirin have been used for treatment.

After treatment with microfilaricidal medications, patients with hyperreactive onchodermatitis (sowda) may be more likely than others to experience severe adverse reactions, especially edema and aggravation of onchodermatitis.

Serious or fatal encephalopathy has been reported rarely in patients with onchocerciasis, and heavily infected with Loa loa, either spontaneously or after treatment with ivermectin. In these patients, pain (including neck and back pain), red eye, conjunctival hemorrhage, dyspnea, urinary and/or fecal incontinence, difficulty in standing/walking, mental status changes, confusion, lethargy, stupor, seizures, or coma have been reported. This syndrome has been seen very rarely following the use of ivermectin therapy. Pretreatment assessment for loiasis and careful posttreatment follow-up should be implemented in all patients considered for treatment with ivermectin for any reason and who had exposure to Loa loa endemic areas of West and Central Africa.

The patient should be advised of the need for repeated stool examinations to document clearance of infection with Strongyloides stercoralis.

The patient should be advised that treatment with ivermectin does not kill the adult Onchocerca parasites, and therefore repeated follow-up and retreatment is usually necessary.

In immunocompromised (including HIV-infected) patients being treated for intestinal strongyloidiasis, repeated courses of therapy may be necessary. Adequate and well-controlled clinical trials have not been conducted in such patients to determine the optimal dosing regimen. Several treatments, i.e., at 2-week intervals, may be required, and cure may not be attained. Control of extraintestinal strongyloidiasis in these patients is difficult, and suppressive therapy, i.e., once per month, may be useful.

Ivermectin is extensively metabolized in the liver and should be used cautiously in patients with hepatic disease. Dosage adjustments may be needed, although specific recommendations are not currently available. The manufacturer does not recommend that ivermectin treatment be excluded in patients with liver disease.

Clinical trials of ivermectin did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently from younger patients. Other reported clinical experience has not identified differences in responses between elderly and younger patients. In general, treatment of elderly patients should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

Safety and effectiveness in pediatric patients weighing less than 15 kg have not been determined.

What is current status about Ivermectin?

We will be waiting for the results of more clinical trials in patients to see how well ivermectin works in treating COVID-19.

The randomized clinical trials need to have a high quality of evidence, without the limitations of risk of bias, imprecision, inconsistency between studies, and indirectness of publication bias.

As Ivermectin is already a FDA approved medicine we already know that it has been established as safe for human use when used at the standard dose.

Conlusion

Ivermectin should not be used in patients for COVID-19, unless it is part of a clinical trial.
Currently there is not enough high quality evidence supporting the use of ivermectin for COVID-19 treatment. More randomized clinical trials with a higher certainty of evidence are needed for ivermectin in the treatment COVID-19.

Ivermectin tablets are FDA approved medicine for some types of intestinal worms and ivermectin cream is FDA approved for rosacea treatment.

Both oral and topical ivermectin have a good safety profile at standard dosing levels.

Ivermectin is not FDA approved to treat COVID-19 patients. Ivermectin should only be used in patients for COVID-19 treatment in a research setting, as part of a clinical trial.

Ivermectin products that are approved for use in animals should NOT be taken by humans. Veterinary products are formulated to treat large animals and contain far higher levels of ivermectin than products approved for human use.

IVERMECTIN COVID-19 Medicines

IVECOP 12MG

$40$108
Generic Name  Ivermectin Treatment For  Scabies, Filariasis Manufacturer Menarini India Pvt Ltd Power 12mg Packaging 1 Tablet in 1 Strip

IVECOP 3MG

$17$46
Generic Name  Ivermectin Treatment For  Scabies, Filariasis Manufacturer Menarini India Pvt Ltd Power 3mg Packaging 2 Tablets in 1 Strip

IVECOP 6MG

$18$53
Generic Name  Ivermectin Treatment For  Scabies, Filariasis Manufacturer Menarini India Pvt Ltd Power 6mg Packaging 1 Tablets in 1 Strip

IVERHEAL 12MG (IVERMECTIN 12MG)

$69$880
Ivermectin is the active ingredient in Iverheal 12mg. The tablet contains 12 mg of salt, which has anti-parasitic properties. The drug is best known for its ability to combat intestinal parasites. If you have a worm infection in the stomach, you can take medication to see how it affects the parasites’ development and the problems they cause in the body. Buy Iverheal 12mg Ivermectin 12 mg now with 10% discount.

IVERHEAL 3MG (IVERMECTIN 3MG)

$75$660
Iverheal 3mg is a medicine used widely against the treatment of infection caused by different parasites. It is recommended to consult with a medical practitioner before starting your medication with Iverheal 3mg. There is some information that also comes in the package of medicine. You can read all the instructions and they give you some ideas about the conception of medicine. Iverheal 3mg can be purchased from a variety of sources, including online and offline stores. Iverheal 3 online because online shopping is the best option to buy medicines. You can buy with legit and trustworthy website called genericpride.com

IVERHEAL 6MG (IVERMECTINE 6MG)

$48$710
Ivermectin 6mg Tablet helps treat many parasitic infections of your intestinal tract, skin, and eyes. It works by paralyzing and killing the parasites causing the infection. This medicine usually makes you feel better quite quickly. Buy online Iverheal 6mg with discount. Ivermectin 6mg buy now here. Ivermectin 3mg,Ivermectin 6mg , Ivermectin 12mg dosage also available.

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